Evaluation of the Diagnostic Performance of theSysmex XT-2000i Automated Hematology Analyzerin the Detection of Immature Granulocyte

Immature Granulocytes (IG) are normally not present in peripheral blood. Their presence is an important indicator of enhanced bone marrow activation. The present study evaluated the diagnostic performance of the Sysmex XT-2000i automated hematology analyzer in the detection of myelocytes and/or metamyelocytes in patients affected by non-haematological disease, in comparison with manual microscopy review (NCCLS H20-A) and also in comparison with Sysmex XE-2100, used as a predicate device. Sysmex XT-2000i shows good specificity and sensitivity in the detection of low, medium and high concentrations of immature myeloid cells. The diagnostic performance of the XT-2000i IG and LS flags is very high and comparable to the results obtained with Sysmex XE-2100. These results suggest that Sysmex XT-2000i would be an excellent second analyser for larger laboratories concerned with harmonization of instrumentation (in particular as a back-up for Sysmex XE-2100), or as a primary instrument for medium-sized routine or STAT laboratories.